C. S. Fraser

Human eukaryotic initiation factor 4G directly binds the 40S ribosomal subunit to promote efficient translation.

This study identifies a direct interaction between eIF4G and the 40S ribosomal subunit, independent of eIF3, and shows that the eIF4G-RBD enhances translation without requiring m7G cap or mRNA tethering.

p53 controls choice between apoptotic and non-apoptotic death following DNA damage

This study shows p53 regulates whether DNA damage triggers apoptosis or non-apoptotic death, revealing that p53-deficient cells die via MPT-driven necrosis due to high basal respiration.

Monitoring RNA restructuring in a human cell-free extract reveals eIF4A-dependent and eIF4A-independent unwinding activity.

This study uses a fluorescent duplex unwinding assay to show that eIF4A and eIF4A-independent mechanisms each contribute 50% to duplex unwinding in cell-free extracts, with the m7G cap promoting unwinding.

5' Untranslated mRNA Regions Allow Bypass of Host Cell Translation Inhibition by Legionella pneumophila

This study identifies host proteins selectively synthesized during Legionella pneumophila infection and shows that 5' untranslated regions (5UTRs) enable translation of low-abundance transcripts despite host translation inhibition.

eIF5B and eIF1A remodel human translation initiation complexes to mediate ribosomal subunit joining

This study uses single-molecule techniques and cryo-EM to show how eIF1A and eIF5B remodel initiation complexes to facilitate ribosomal subunit joining during translation initiation.