An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
K. Jain, M. R. Marunde, J. M. Burg, S. L. Gloor, F. M. Joseph, K. F. Poncha, Z. B. Gillespie, K. L. Rodriguez, I. K. Popova, N. W. Hall, A. Vaidya, S. A. Howard, H. F. Taylor, L. Mukhsinova, U. C. Onuoha, , B. D. Strahl
The paper shows that H3 tail acetylation enhances accessibility of both H3K4 methyl readers and writers, revealing an acetylation-mediated chromatin switch that modulates H3K4 methylation read-write capability.
bioRxiv · Feb 28, 2022Biochemistry