Author

A. Bolotokova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

F. Li· 5 shared M. Vedadi· 4 shared P. Ghiabi· 4 shared S. Perveen· 4 shared A. Khalili Yazdi· 3 shared I. Chau· 3 shared K. Devkota· 3 shared M. Schapira· 3 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersBiochemistry

F. Li

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Author profile →

5 papers

Recent·Most cited

A resource to enable chemical biology and drug discovery of WDR Proteins

C. H. Arrowsmith, S. Ackloo, F. Li, M. Szewczyk, A. Seitova, P. Loppnau, H. Zeng, S. Ahmad, S. Beldar, A. Bolotokova, I. Chau, S. Dehghani-Tafti, A. Dong, P. Ghiabi, E. Gibson, , Arnautova

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

bioRxiv · Mar 3, 2024Biochemistry

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

D. Dilworth, R. P. Hanley, R. Ferreira de Freitas, A. Allali-Hassani, M. Zhou, N. Mehta, M. R. Marunde, S. Ackloo, E. Marcon, F. Li, I. Chau, A. Bolotokova, S. Qin, M. Lei, Y. Liu, , M. Schapira

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

bioRxiv · Mar 5, 2021 · PreprintCell Biology

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

K. Devkota, M. Schapira, S. Perveen, A. Khalili Yazdi, F. Li, I. Chau, P. Ghiabi, T. Hajian, P. Loppnau, A. Bolotokova, K. J. Satchell, K. Wang, D. Li, J. Liu, D. Smil, , M. Vedadi

This paper identifies SAM competitive inhibitors of SARS-CoV-2 nsp14 methyltransferase and characterizes their mechanism, guiding the development of selective bi-substrate inhibitors.

bioRxiv · Feb 19, 2021Biochemistry

A high-throughput radioactivity-based assay for screening SARS-CoV-2 nsp10-nsp16 complex

A. Khalili Yazdi, F. Li, K. Devkota, S. Perveen, P. Ghiabi, T. Hajian, A. Bolotokova, M. Vedadi

The paper develops a radioactivity-based high-throughput screening assay for the SARS-CoV-2 nsp10-nsp16 complex and optimizes it for HTS with a Z'-factor of 0.83.

bioRxiv · Feb 3, 2021Biochemistry

A high throughput RNA displacement assay for screening SARS-CoV-2 nsp10-nsp16 complex towards developing therapeutics for COVID-19

S. Perveen, A. Khalili Yazdi, K. Devkota, F. Li, P. Ghiabi, T. Hajian, P. Loppnau, A. Bolotokova, M. Vedadi

The paper develops a fluorescence polarization assay for screening RNA-competitive inhibitors of the SARS-CoV-2 nsp10-nsp16 complex, validated with 1124 compounds.

bioRxiv · Oct 14, 2020Biochemistry