Author

N. Z. Jespersen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 1

Frequent Co-Authors

S. Nielsen· 4 shared B. K. Pedersen· 3 shared C. Scheele· 3 shared L. Peijs· 2 shared R. Soares· 2 shared A. Josephrajan· 1 shared A. Pfeifer· 1 shared A. R. A. d. A. Tavanez· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCell Biology

S. Nielsen

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Author profile →

4 papers

Recent·Most cited

Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function.

S. Khani, H. Topel, A. Josephrajan, B. D. M. Larsen, A. R. A. d. A. Tavanez, M. J. Gaudry, P. Leyendecker, N. Stanic, I. Gaziano, N. R. Hansmeier, E. Schmidt, P. Klemm, L.-M. Vagliano, C. A. Engelhard, S. Nielsen, , J.-W. Kornfeld

The paper identifies a cold-inducible truncated Adcy3 mRNA isoform, Adcy3-at, which acts as a rheostat to regulate brown fat function by limiting cAMP activity during obesity.

bioRxiv · Aug 1, 2022Cell Biology

Thermogenic genes are blunted whereas brown adipose tissue identity is preserved in human obesity

N. Z. Jespersen, M. W. Andersen, V. H. Jensen, T. W. Staerker, M. C. Severinsen, L. Peijs, R. Soares, I. Forss, E. S. Andersen, C. H. Hahn, P. Homee, S. Mandrup, B. K. Pedersen, S. Nielsen, C. Scheele

The paper identifies a reduction in thermogenic genes but preserved brown adipose tissue identity in human obesity through transcriptomic analysis of BAT and WAT.

bioRxiv · May 7, 2020 · PreprintCell Biology

Proteomics-based comparative mapping of the human brown and white adipocyte secretome reveals EPDR1 as a novel batokine

A. S. Deshmukh, L. Peijs, S. Nielsen, R. Bayarri-Olmos, T. J. Larsen, N. Z. Jespersen, H. Hattel, B. Holst, P. Garred, M. Tang-Christensen, A. Sanfridson, Z. Gerhart-Hines, B. K. Pedersen, M. Mann, C. Scheele

The paper compares the secretomes of human brown and white adipocytes using proteomics, identifying EPDR1 as a novel batokine involved in thermogenesis and energy consumption.

bioRxiv · Aug 30, 2018Physiology

A long-non-coding RNA, LINC00473, confers the human adipose tissue thermogenic phenotype through enhanced cAMP responsiveness.

K.-V. Tran, C. Nandrup-Bus, T. DeSouza, R. Soares, N. Z. Jespersen, S. Y. Min, R. Rojas-Rodriguez, H. Willenbrock, T. Juhlin, M. C. K. Severinsen, K. Malka, B. K. Pedersen, T. Fitzgibbons, C. Scheele, S. Corvera, S. Nielsen

This study identifies LINC00473 as a key regulator of thermogenic adipocyte function, showing its role in enhancing cAMP responsiveness and mitochondrial activity.

bioRxiv · Jun 5, 2018Cell Biology