Human spastin functions as an ATPase-independent microtubule nucleator via ring-stack formation
Hanjin Liu, Nao Matsumoto, Toshiyuki Kaneshiro, Takaaki Kato, Hideki Shigematsu, Satoshi Kikkawa, Eriko Nitta, Tsuyoshi Imasaki, Ryo Nitta
This study shows human spastin functions as an ATPase-independent microtubule nucleator by forming ring-stack structures, redefining its role in microtubule dynamics and HSP pathology.
bioRxiv · Nov 28, 2025 · PreprintBiophysics