BRM preserves sinusoidal niche resilience through Jag2-Notch signaling during hematopoietic regeneration and aging
Haruka Suzuki, Hiroki Miyachi, Natsuka Yamada, Hiroki Nishikawa, Shuhei Kuno, Hiromi Endoh, Tatsuro Shiina, Ryo Yoshikawa, Shun Uemura, Atsushi Iwama, Toshio Suda, Eriko Nitta
This study identifies BRM as a critical regulator of bone marrow sinusoidal niche integrity and hematopoietic regeneration, showing that its decline with age contributes to niche dysfunction and hematopoietic aging.
bioRxiv · Oct 8, 2026 · PreprintImmunology