Tsuyoshi Imasaki

This study determines cryo-EM structures of the E. coli BAM complex in different environments, identifying new conformational states involved in lateral-gate closure during OMP insertion.

This study identifies CAMSAP2 condensates as a γ-TuRC-independent mechanism for non-centrosomal microtubule nucleation through phase separation and tubulin organization.

This paper reports high-resolution structures of kinesin-14 motor proteins during different mechanochemical states, revealing structural transitions that drive force generation and the power stroke.

This study shows human spastin functions as an ATPase-independent microtubule nucleator by forming ring-stack structures, redefining its role in microtubule dynamics and HSP pathology.

This study identifies amino acid substitutions in KIF5A from giraffes and pythons that enhance axonal transport speed, revealing convergent evolutionary adaptations for long-distance transport.

The paper uses optogenetics and cryo-ET to visualize actin cytoskeleton dynamics during lamellipodia formation, revealing distinct structural phases and actin turnover mechanisms.

This study presents cryo-EM structures of GAS2 domains bound to actin and microtubules, revealing their roles in cytoskeletal organization and dimerization.

The paper determines the X-ray crystal structure of human ASNS and builds a computational model of the enzyme-inhibitor complex to understand specificity.

The paper develops a method to estimate initial infectivity and optimize protein production using the baculovirus expression vector system.