Author

Naomi A. S. Span

Eindhoven University of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:protein structure· 1

Frequent Co-Authors

Aitana de la Cuadra BastéiD· 1 shared Alessio CiulliiD· 1 shared Carlo J. A. VerhoefiD· 1 shared Charlotte CroweiD· 1 shared Christian OttmanniD· 1 shared Gajanan J. SatheiD· 1 shared Kentaro IsoiD· 1 shared Luc BrunsveldiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

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1 paper

Recent·Most cited

Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design

Carlo J. A. Verhoef, Charlotte Crowe, Mark A. Nakasone, Aitana de la Cuadra Basté, Tessa Harzing, Naomi A. S. Span, Gajanan J. Sathe, Kentaro Iso, Christian Ottmann, Luc Brunsveld, Alessio Ciulli, Peter J. Cossar

This paper develops a molecular glue-based PROTAC (MGPROTACs) to ubiquitinate the 14-3-3/Estrogen Receptor complex, demonstrating cooperative complex formation and selective ubiquitination through linker design.

bioRxiv · Nov 17, 2025 · PreprintBiochemistry