Tony D. Southall

The paper shows that oncogenic outcomes of dedifferentiation in Drosophila CNS vary by region, mediated by Chinmo and ecdysone signaling.

This study identifies a splicing-independent role for Sxl in regulating RNA Polymerase III activity and tRNA synthesis in Drosophila neurons, impacting neuronal metabolism and ageing.

The paper identifies RPN1 as a novel regulator of IRE1 RNase activity through interaction with IRE1 and PERK complexes in Drosophila.

The paper shows Mi-2 activity represses ectopic gene expression in neurons independently of NuRD, highlighting its role in establishing stable neuronal transcriptomes during early differentiation.

The paper identifies how Shavenbaby isoforms regulate gene expression and chromatin structure during Drosophila intestinal stem cell differentiation.

AGES provides a non-lethal, cost-effective method to temporally control GAL4 activity in Drosophila by using auxin to degrade GAL80, enabling precise gene expression regulation.

The paper identifies regulatory regions and gene regulatory networks in Drosophila brain cell types using chromatin accessibility and transcriptome data.

This study identifies a novel crosstalk between Drosophila intestinal stem cells and the tracheal system, showing that reactive oxygen species drive tracheal plasticity to support intestinal regeneration.

The paper introduces FlyORF-TaDa, a system that rapidly generates transgenic Drosophila lines for cell-type specific profiling of protein-DNA interactions using existing FlyORF libraries.

The paper identifies transcription factors uniquely expressed or depleted in specific neurotransmitter types during Drosophila development and shows they directly bind key neuronal genes.

This study shows that Cap-G, a condensin I subunit, is essential for proper gene expression in post-mitotic neurons, leading to developmental arrest and gene expression changes when knocked down.

The paper identifies how spatial and temporal cues integrate in Drosophila neuroblasts through chromatin landscapes to generate neuronal diversity.

The paper uses an in vivo method to profile chromatin accessibility in Drosophila stem cell lineages, revealing dynamic changes during differentiation.

The paper characterizes the complex Lola locus in Drosophila by generating isoform-specific mutations, revealing distinct roles in axon guidance and neurodegeneration via the octopaminergic pathway.