Chromosome 7 gain establishes a just-right WNT signaling state during colorectal tumorigenesis
Irene C. Zaalberg, Paula C. Gasull, Martijn J.M. Vromans, Meritxell Brunet Guasch, Natalia Marcekova, Anna Vinken, Sjors Middelkamp, René Wardenaar, Daniëlle Koot, Beatriz G. Carvalho, Hugo J.G. Snippert, Michael D. Nicholson, Floris Foijer, Michaël Schubert, Susanne M. A. Lens
This study shows that chromosome 7 gain optimizes WNT signaling in colorectal cancer by counteracting excessive stemness from APC mutations.
bioRxiv · Oct 14, 2026 · PreprintCancer Biology