USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms
Matthew G Williamson, Rachel Heon‐Roberts, Sarah N. J. Franks, Elliot D. Mock, Hannah B. L. Jones, Elena Britti, Ana Belén Malpartida, Mahmoud Adel Bassal, Martha Lavelle, Jack P. Connor, Aina Mogas Barcons, Katherine L. Hammond, Katrina Savory, Pavandeep Rai, Anna Lavayssiere, , Brent James Ryan
This study shows USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms, enhancing mitophagy and mitochondrial efficiency in neurons.
bioRxiv · Feb 3, 2025 · PreprintNeuroscience