Author

Philipp Trepte

Institute of Molecular BiotechnologyORCID 0000-0002-8141-6272Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 3 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Erich E. WankeriD· 4 shared Christopher SeckeriD· 3 shared DAVID EDWIN HILLiD· 3 shared Eduardo Silva RamosiD· 3 shared Jean‐Claude TwizereiD· 3 shared Julien OlivetiD· 3 shared Kerstin SpirohniD· 3 shared Marc VidaliD· 3 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersSystems Biology

Erich E. WankerORCID

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5 papers

Recent·Most cited

Cell BiologybioRxivPreprintApr 1, 2026

HAP40 functions as a proteostasis regulator by controlling huntingtin interactions and its release into the extracellular space

Eduardo Silva Ramos, Annett Boeddrich, Christian Haenig…·Erich E. Wanker

This study identifies HAP40 as a proteostasis regulator that controls HTT interactions and mHTT secretion, impacting cellular homeostasis and pathobiology.

1 citation

humanproteomics

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Systems BiologyMolecular Systems BiologyPeer-reviewedMar 11, 2024

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Philipp Trepte, Christopher Secker, Julien Olivet…·Erich E. Wanker

The paper presents an AI-guided pipeline for PPI drug discovery, identifying a SARS-CoV-2 inhibitor by combining experimental assays, machine learning, and virtual screening.

35 citationstop 2%

protein structuremachine learning (classical)

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Developmental BiologyeLifePeer-reviewedMar 17, 2023

Integrated transcriptome and proteomeanalysis in human brain organoids revealsposttranscriptional regulation of ribosomalgenes.

Jaydeep Sidhaye, Philipp Trepte, Natalie Sepke…·Juergen A. Knoblich

The paper integrates transcriptome and proteome data from human brain organoids to uncover posttranscriptional regulation of ribosomal genes during corticogenesis.

33 citationstop 5%

humanbulk RNA-seq

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Systems BiologybioRxivPreprintAug 25, 2021

A quantitative mapping approach to identify direct interactions within complexomes

Philipp Trepte, Christopher Secker, Soon Gang Choi…·Erich E. Wanker

The paper presents a framework combining two high-throughput interaction assays to distinguish direct from indirect protein interactions in complexes.

2 citations

proteomicsexperimental assay

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Systems BiologyNature CommunicationsPeer-reviewedAug 29, 2019

Maximizing binary interactome mapping with a minimal number of assays

Soon Gang Choi, Julien Olivet, Patricia Cassonnet…·Yves Jacob

The paper introduces an assayome concept to optimize binary interactome mapping by combining multiple assay versions, achieving high true positive detection with minimal assays.

78 citations

protein structureexperimental assay

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