Author

Nathalia Aprahamian

Montreal Neurological Institute and Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Carol X.‐Q. CheniD· 3 shared Thomas M. DurcaniD· 3 shared Ghazal HaghiiD· 2 shared Mathilde ChaineauiD· 2 shared Michaël NicouleauiD· 2 shared Zhipeng You· 2 shared Aeshah Alluli· 1 shared Alva AnnettiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Carol X.‐Q. ChenORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

USP15 REGULATES NEUROINFLAMMATION AND DRIVES PATHOGENESIS IN SYNUCLEINOPATHIES

Nassima Fodil, Esther del Cid‐Pellitero, Valerio E. C. Piscopo, Julia Xiao Xuan Luo, Michael Wong, Jean-Frédéric Olivier, Aeshah Alluli, Irina Shlaifer, Zhipeng You, Carol X.‐Q. Chen, Nathalia Aprahamian, Yoonjeong Cha, Etienne Colette, Jonas J. Mayo, Alva Annett, , Philippe Gros

This study shows that USP15 deletion in astrocytes and microglia reduces neuroinflammation and slows synucleinopathy progression in mice, with human data linking USP15 expression to Parkinson's disease risk.

bioRxiv · Sep 12, 2026 · PreprintNeuroscience

Targeting calpastatin pharmacologically restores synaptic proteolysis and preserves motor neurons survival and function in C9orf72 ALS

Léa Lescouzères, Zoé Butti, Mathilde Chaineau, Daniel W Young, Zhipeng You, Michaël Nicouleau, Carol X.‐Q. Chen, Ghazal Haghi, Nathalia Aprahamian, Charlotte Zaouter, Antoine Dufour, Thomas M. Durcan, Shunmoogum A. Patten

This study shows that restoring calpastatin activity improves motor neuron function and survival in C9orf72 ALS models by enhancing synaptic proteolysis and NMJ integrity.

bioRxiv · May 11, 2026 · PreprintNeuroscience

Mutations in SOD1 induce ALS-related phenotypes in 3D iPSC-derived motor neuron (MN) spheroids

María José Castellanos‐Montiel, Anna Kristina Franco-Flores, Michaël Nicouleau, Ghazal Haghi, Sarah Lépine, Belén Baeza, Carol X.‐Q. Chen, Taylor Goldsmith, Nathalia Aprahamian, Doris Hua, Mathilde Chaineau, Lale Gursu, Narges Abdian, Éric Deneault, Thomas M. Durcan

This study uses 3D iPSC-derived motor neuron spheroids with SOD1 mutations to show ALS-related phenotypes and genetic variability effects.

bioRxiv · Jan 28, 2025 · PreprintNeuroscience