Author

Léa Lescouzères

Centre National de la Recherche ScientifiqueORCID 0000-0002-7115-7342Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Anne TaupignoniD· 1 shared Antoine DufouriD· 1 shared Carol X.‐Q. CheniD· 1 shared Charlotte Zaouter· 1 shared Daniel W YoungiD· 1 shared Emmanuel ValjentiD· 1 shared Ghazal HaghiiD· 1 shared Jérémy Cousineau· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Anne TaupignonORCID

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2 papers

Recent·Most cited

Targeting calpastatin pharmacologically restores synaptic proteolysis and preserves motor neurons survival and function in C9orf72 ALS

Léa Lescouzères, Zoé Butti, Mathilde Chaineau, Daniel W Young, Zhipeng You, Michaël Nicouleau, Carol X.‐Q. Chen, Ghazal Haghi, Nathalia Aprahamian, Charlotte Zaouter, Antoine Dufour, Thomas M. Durcan, Shunmoogum A. Patten

This study shows that restoring calpastatin activity improves motor neuron function and survival in C9orf72 ALS models by enhancing synaptic proteolysis and NMJ integrity.

bioRxiv · May 11, 2026 · PreprintNeuroscience

Dopamine D2 receptors modulate intrinsic properties and synaptic transmission of parvalbumin interneurons in the mouse primary motor cortex

Jérémy Cousineau, Léa Lescouzères, Anne Taupignon, Lorena Delgado-Zabalza, Emmanuel Valjent, Jérôme Baufreton, Morgane Le Bon-Jégo

This study shows that dopamine D2 receptors in parvalbumin interneurons of the mouse primary motor cortex increase neuronal excitability and GABAergic synaptic transmission to pyramidal neurons.

eNeuro · Apr 22, 2020Peer-reviewedNeuroscience