A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency
Xin Huang, Nazym Bashkenova, Yantao Hong, Cong Lyu, Diana Guallar, Zhe Hu, Vikas Malik, Dan Li, Hailin Wang, Xiaohua Shen, Hongwei Zhou, Jianlong Wang
This study identifies a TET1-PSPC1-Neat1 molecular axis that modulates PRC2 binding to chromatin and bivalent gene transcripts during stem cell state transitions.
Cell Reports · Jun 1, 2022Peer-reviewedDevelopmental Biology