Hongwei Zhou

Mapping early PRC2 nucleation sites upon Suz12 reintroduction reveals features of de novo Polycomb recruitment

The paper identifies PRC2 nucleation sites in mESCs after Suz12 reintroduction, revealing chromatin states, DNA sequences, cofactors, and spatial interactions involved in de novo Polycomb recruitment.

Enforced ZFP281 expression delays breast cancer initiation and can provide lifelong protection against breast cancer metastasis

This study shows that ZFP281 expression delays breast cancer initiation and prevents metastasis by enforcing a dormant state in cancer cells.

ZFP281 coordinates DNMT3 and TET1 for transcriptional and epigenetic control in pluripotent state transitions

This study identifies ZFP281 as a coordinator of DNMT3A/3B and TET1 to regulate DNA methylation and gene expression during pluripotent stem cell state transitions.

The pluripotency factor Tex10 finetunes Wnt signaling for PGC and male germline development

This study identifies Tex10 as a regulator of Wnt signaling in PGC specification and male germline development using mouse models and single-cell RNA sequencing.

A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency

This study identifies a TET1-PSPC1-Neat1 molecular axis that modulates PRC2 binding to chromatin and bivalent gene transcripts during stem cell state transitions.

eIF4A2 targets developmental potency and histone H3.3 transcripts for translational control of stem cell pluripotency

This study identifies eIF4A2 as a key translation initiation factor that regulates stem cell pluripotency by controlling the translation of pluripotency factors and histone H3.3.