Dan Li

This paper introduces L-PGI, a ligase-mediated gene editing system that enables efficient and precise genomic integration in both dividing and nondividing cells, overcoming limitations of reverse transcriptase-based methods.

This study identifies Tex10 as a regulator of Wnt signaling in PGC specification and male germline development using mouse models and single-cell RNA sequencing.

This study identifies a TET1-PSPC1-Neat1 molecular axis that modulates PRC2 binding to chromatin and bivalent gene transcripts during stem cell state transitions.

This study identifies eIF4A2 as a key translation initiation factor that regulates stem cell pluripotency by controlling the translation of pluripotency factors and histone H3.3.