Xin Huang

The paper identifies PRC2 nucleation sites in mESCs after Suz12 reintroduction, revealing chromatin states, DNA sequences, cofactors, and spatial interactions involved in de novo Polycomb recruitment.

This study shows EHD1 promotes inflammation and stabilizes sortilin in macrophages, accelerating atherosclerosis through enhanced TNFR2-NF-kB signaling and endocytic recycling.

This study identifies ZFP281 as a coordinator of DNMT3A/3B and TET1 to regulate DNA methylation and gene expression during pluripotent stem cell state transitions.

This study identifies Tex10 as a regulator of Wnt signaling in PGC specification and male germline development using mouse models and single-cell RNA sequencing.

This study identifies a TET1-PSPC1-Neat1 molecular axis that modulates PRC2 binding to chromatin and bivalent gene transcripts during stem cell state transitions.

This study identifies eIF4A2 as a key translation initiation factor that regulates stem cell pluripotency by controlling the translation of pluripotency factors and histone H3.3.