Xiaohua Shen

Translation sustains productive Pol II elongation through maintenance of nuclear RNA surveillance

This study shows that ongoing translation sustains productive Pol II elongation and nuclear RNA homeostasis in mouse embryonic stem cells by maintaining RNA surveillance.

Co-transcriptional RNA processing boosts zygotic gene activation

This study shows that co-transcriptional RNA processing via the CTD of Pol II is essential for zygotic gene activation, as disrupting it halts mRNA synthesis and increases noncoding RNA levels.

A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency

This study identifies a TET1-PSPC1-Neat1 molecular axis that modulates PRC2 binding to chromatin and bivalent gene transcripts during stem cell state transitions.

U1 snRNP regulates chromatin retention of noncoding RNAs

The paper identifies a U1 snRNP recognition motif that regulates chromatin retention of noncoding RNAs through experimental and computational methods.

L1 and B1 repeats blueprint the spatial organization of chromatin

This study identifies L1 and B1 retrotransposons as key elements shaping the 3D chromatin structure through spatial compartmentalization in human and mouse cells.

The long noncoding RNA Hand2as orchestrates heart development through regulation of precise expression of HAND2

This study identifies Hand2as as a key lncRNA regulating HAND2 expression in heart development through single-cell RNA sequencing and knockout models, leading to congenital defects and perinatal lethality.