Author

Yantao Hong

Center for Life Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Developmental Biology· 2 Molecular Biology· 2 Genomics· 1

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Approach:experimental assay· 5 Research Focus:gene regulatory network inference· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Assay:ChIP-seq· 2 Assay:DNA methylation· 2

Frequent Co-Authors

Xiaohua SheniD· 5 shared Jie NaiD· 2 shared Wen Shao· 2 shared Xiaowen Hao· 2 shared Yafei YiniD· 2 shared Zai Chang· 2 shared Bin TianiD· 1 shared Cong Lyu· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersMolecular Biology

Xiaohua ShenORCID

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5 papers

Recent·Most cited

Translation sustains productive Pol II elongation through maintenance of nuclear RNA surveillance

Mengyuan Huang, Yantao Hong, Ruiqi Deng, Yilin Liu, Yi Zhou, Xiaowen Hao, Zheng Zheng, Linqing Xing, Xiaohua Shen

This study shows that ongoing translation sustains productive Pol II elongation and nuclear RNA homeostasis in mouse embryonic stem cells by maintaining RNA surveillance.

bioRxiv · Jun 23, 2026 · PreprintMolecular Biology

Co-transcriptional RNA processing boosts zygotic gene activation

Jingzhao Xu, Xiaojing Li, Xiaowen Hao, Xinyun Hu, Shaoqian Ma, Yantao Hong, Jing Zhang, Dingfei Yan, Haiteng Deng, Jie Na, Xiong Ji, Zai Chang, Xiaohua Shen

This study shows that co-transcriptional RNA processing via the CTD of Pol II is essential for zygotic gene activation, as disrupting it halts mRNA synthesis and increases noncoding RNA levels.

bioRxiv · Sep 14, 2024 · PreprintDevelopmental Biology

A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency

Xin Huang, Nazym Bashkenova, Yantao Hong, Cong Lyu, Diana Guallar, Zhe Hu, Vikas Malik, Dan Li, Hailin Wang, Xiaohua Shen, Hongwei Zhou, Jianlong Wang

This study identifies a TET1-PSPC1-Neat1 molecular axis that modulates PRC2 binding to chromatin and bivalent gene transcripts during stem cell state transitions.

Cell Reports · Jun 1, 2022Peer-reviewedDevelopmental Biology

U1 snRNP regulates chromatin retention of noncoding RNAs

Yafei Yin, Jiayun Lu, Xuechun Zhang, Wen Shao, Yanhui Xu, Pan Li, Yantao Hong, Li Cui, Ge Shan, Bin Tian, Qiangfeng Cliff Zhang, Xiaohua Shen

The paper identifies a U1 snRNP recognition motif that regulates chromatin retention of noncoding RNAs through experimental and computational methods.

Nature · Mar 11, 2020Peer-reviewedMolecular Biology

L1 and B1 repeats blueprint the spatial organization of chromatin

J. Yuyang Lu, Lei Chang, Tong Li, Ting Wang, Yafei Yin, Ge Zhan, Ke Zhang, Michelle Percharde, Liang Wang, Qi Peng, Pixi Yan, Hui Zhang, Xue Han, Xianju Bi, Wen Shao, , Xiaohua Shen

This study identifies L1 and B1 retrotransposons as key elements shaping the 3D chromatin structure through spatial compartmentalization in human and mouse cells.

bioRxiv · Oct 13, 2019 · PreprintGenomics