Sharon Kaisari

Cyclin D-CDK4/6 couple proliferation to membrane and mitochondrial protein supply through a DeSI1 phospho-switch

This study identifies DeSI1 as a cyclin D-CDK4/6 substrate whose phosphorylation regulates membrane and mitochondrial protein supply during proliferation.

Pan-cancer proteogenomic interrogation of the Ubiquitin Proteasome System

Proteogenomic analysis of up to 11 CPTAC cohorts shows ubiquitin-proteasome proteins often diverge from transcripts; TP53-mutant tumors elevate UBR5 protein, while TRIM28 prognosis is lineage-dependent.

GMCL1 Controls 53BP1 Stability and Modulates Taxane Sensitivity

This study identifies GMCL1 as a negative regulator of the mitotic stopwatch pathway, showing it promotes 53BP1 degradation and reduces paclitaxel sensitivity in cancer cells.

Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under Oxidative Stress

This study reveals how two F-box proteins, FBXO22 and FBXL17, recognize distinct structural features of the BACH1 BTB dimer under oxidative stress, leading to its ubiquitination and degradation.

Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis

The paper shows cyclin D1-CDK4/6 stabilizes GTSE1, promoting cell proliferation and poor cancer prognosis.