Yongqiang Liu

This study identifies DMT3 as a 6mA demethylase in unicellular eukaryotes and shows its role in maintaining transcriptional and developmental integrity by preventing ectopic 6mA deposition at TSS.

This study identifies IBD1 as a bridge between histone acetylation and H2A.Z deposition, showing its role in maintaining transcriptional homeostasis by preventing hyperactivation.

The paper identifies two distinct methyltransferase complexes that coordinate to maintain DNA N6-methyladenine (6mA) through different mechanisms during replication and transcription.

The paper demonstrates that DNA N6-adenine methylation (6mA) is transmitted semi-conservatively in Tetrahymena thermophila, with AMT1-dependent maintenance and AMT1-independent de novo methylation mechanisms.

The paper shows frameshift proteins are more similar to wild-type proteins than random, indicating the genetic code and genomes are optimized for frameshift tolerance.