Targeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma
Kelsey Keith, Min Peng, Cristina Remeş, Victoria Miranda, Nicholas A Wachowski, Melis Kose, Shrikant Dhraskar, Suraiya Haroon, Agustin B. Velasco, Priya Sivaramakrishnan, Donna M. Iadarola, Sundeep Dugar, Marni J. Falk
The paper identifies THPO, IGF1, and MAPK as therapeutic targets for mitochondrial respiratory chain disease and osteosarcoma, showing their modulation can replicate the benefits of CHX treatment.
bioRxiv · Jul 24, 2026 · PreprintGenetics