Min Peng

Targeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma

The paper identifies THPO, IGF1, and MAPK as therapeutic targets for mitochondrial respiratory chain disease and osteosarcoma, showing their modulation can replicate the benefits of CHX treatment.

Targeted protein degradation via CAR endocytosis of antigen in T cells

This paper develops a TPD platform using CAR T cells to degrade extracellular TNF, achieving disease remission in a rheumatoid arthritis model.

In vitro modeling of nutritional and mitochondria-targeted therapies for osteosarcoma

This study evaluates metabolic and mitochondria-targeted therapies for osteosarcoma using in vitro models, finding that combined treatments like ONC201/ONC206/metformin show enhanced cytotoxicity with minimal toxicity to normal cells.

FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells

The paper investigates how FANCJ helicase affects PARP1 activity during DNA replication in BRCA1 deficient cells, revealing its role in PARPi efficacy and resistance.