Author

Melis Kose

Children's Hospital of PhiladelphiaORCID 0000-0003-2255-3725Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Cristina RemeşiD· 2 shared Kelsey KeithiD· 2 shared Marni J. FalkiD· 2 shared Suraiya HarooniD· 2 shared Agustin B. Velasco· 1 shared Donna M. IadarolaiD· 1 shared Eiko Nakamaru‐OgisoiD· 1 shared Elizabeth M. McCormickiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenetics

Cristina RemeşORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintJul 24, 2026

Targeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma

Kelsey Keith, Min Peng, Cristina Remeş…·Marni J. Falk

The paper identifies THPO, IGF1, and MAPK as therapeutic targets for mitochondrial respiratory chain disease and osteosarcoma, showing their modulation can replicate the benefits of CHX treatment.

DOI 10.64898/2026.07.20.739625

humanC. elegans

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Molecular BiologybioRxivPreprintMay 26, 2026

Targeting the Mitochondrial Phenotype in Cockayne Syndrome Patient Cells: From Bioenergetic Fragility to Pharmacologic Rescue

Melis Kose, Elizabeth M. McCormick, Kelsey Keith…·Marni J. Falk

This study identifies five compounds that improve mitochondrial function and survival in Cockayne syndrome patient fibroblasts by targeting oxidative stress, autophagy, and cellular resilience.

1 citation

humanbulk RNA-seq

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