Efficient RNA-mediated reprogramming of human somatic cells to naive pluripotency facilitated by tankyrase inhibition
Nicholas Bredenkamp, Jian Ping Yang, James Clarke, Giuliano Giuseppe Stirparo, Ferdinand von Meyenn, Sabine Dietmann, Duncan Baker, Rosalind Drummond, Yongming Ren, Dongwei Li, Chuman Wu, Maria Rostovskaya, Sarah Eminli-Meissner, Austin G Smith, Ge Guo
This paper demonstrates that tankyrase inhibition enables efficient, transgene-free reprogramming of human somatic cells to naive pluripotency, with clonal expansion and differentiation capabilities.
Stem Cell Reports · Nov 7, 2019Peer-reviewedDevelopmental Biology