Rosalind Drummond

The paper shows that ASCL1's ability to induce a neuronal program in pluripotent cells depends on chromatin priming and co-factor availability, with PHOX2B enhancing neuronal differentiation.

The paper compares ASCL1 interactomes in neuroblastoma cell lines to identify CDK2-Cyclin A2 as suppressors of differentiation in MYCN-amplified cells.

The paper uses human iPSC-derived 3D trunk-like structures to study mesodermal lineage decisions and identifies TBX6 and FOXC1/2 as key regulators in human trunk mesoderm diversification.

This paper demonstrates that tankyrase inhibition enables efficient, transgene-free reprogramming of human somatic cells to naive pluripotency, with clonal expansion and differentiation capabilities.