Ge Guo

Human naive stem cell models reveal the role of FGF signalling in hypoblast specification in the human embryo

This study uses human naive PSC models to show FGF signaling is critical for hypoblast specification, revealing conservation with mouse lineage specification.

Suppression of YAP Safeguards Human Naïve Pluripotency

This study identifies YAP suppression as the mechanism by which tankyrase inhibition maintains human naive pluripotency without inducing differentiation.

Human Naive Epiblast Cells Possess Unrestricted Lineage Potential

The paper shows human naive epiblast cells can generate trophectoderm and trophoblast cells, unlike mouse embryonic stem cells, and identifies key regulators of this process.

Efficient RNA-mediated reprogramming of human somatic cells to naive pluripotency facilitated by tankyrase inhibition

This paper demonstrates that tankyrase inhibition enables efficient, transgene-free reprogramming of human somatic cells to naive pluripotency, with clonal expansion and differentiation capabilities.

Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human preimplantation epiblast

Reanalysis of three human embryo scRNA-seq datasets resolves cell-type ambiguities, defines epiblast and primitive endoderm prototypes, and identifies t2iLGö and 5i/L/A naïve stem cells as epiblast-like.

Epigenetic resetting of human pluripotency

This paper describes a method to reset human pluripotent stem cells to a naive state through transient histone deacetylase inhibition, showing transcriptomic and epigenomic changes similar to the inner cell mass.