Sabine Dietmann

The paper identifies a myofibroblast differentiation program during neonatal lung development using single-cell RNA sequencing and lineage tracing in mice.

The paper shows that disabling de novo DNA methylation in embryonic stem cells causes them to adopt a trophoblast fate instead of proper differentiation, due to misexpression of Ascl2.

This study investigates epigenetic reprogramming in pig primordial germ cells, identifying similarities with human germline processes and potential for transgenerational epigenetic inheritance.

The paper identifies and characterizes formative stem cells in mice and humans, showing they have unique transcriptional and epigenetic features compared to naive and primed pluripotent cells.

The paper identifies NSUN6 as a methyltransferase that specifically targets mRNA 3UTR regions with the CTCCA motif, affecting translation termination but not essential for mouse development.

This study profiles transcriptional and morphogenetic features of human gastruloids, identifying seven cell types and conserved sorting behaviors during embryogenesis.

The paper identifies transposable elements resistant to epigenetic resetting in human germline cells and links them to developmental traits and diseases.

This study shows PRDM14 is essential for human PGC fate, contradicting previous findings, and reveals divergent regulatory mechanisms between human and mouse PGCs using inducible degrons.

This paper demonstrates that tankyrase inhibition enables efficient, transgene-free reprogramming of human somatic cells to naive pluripotency, with clonal expansion and differentiation capabilities.

The paper shows that MTA proteins in ES cell NuRD complex are functionally redundant, and NuRD is essential for maintaining differentiation trajectory during early lineage commitment.

This study compares single-cell transcriptomes of human, marmoset, and mouse embryos to identify conserved and divergent features of preimplantation development.

This paper describes a method to reset human pluripotent stem cells to a naive state through transient histone deacetylase inhibition, showing transcriptomic and epigenomic changes similar to the inner cell mass.

This study shows the NuRD complex regulates enhancer chromatin structure and Mediator access to control transcription during lineage commitment in ES cells.