Genome-wide screen in Mycobacterium tuberculosis infected macrophages reveals innate regulation of antibacterial mediators by IRF2
Allison W. Roberts, Linda N. Del Cid, Nicholas E. Garelis, Jeffery S. Cox
The paper identifies IRF2 as a regulator of antibacterial responses in Mtb-infected macrophages through a genome-wide CRISPR screen, showing its inhibitory role in macrophage activation.
bioRxiv · Sep 26, 2025 · PreprintImmunology