Jeffery S. Cox

This study shows that ESX-5 deletions in Mtb reduce cytokine secretion in macrophages via a post-transcriptional mechanism and alter heavy metal response genes.

This paper uses synthetic biology to engineer BCG to produce HMBPP, enhancing Vγ9Vδ2 T cell expansion without feedback inhibition, offering a strategy to improve TB vaccine efficacy.

This study shows Tax1bp1 promotes Mtb growth in alveolar macrophages and enhances inflammatory responses, while restricting Mtb in bone marrow-derived macrophages.

This study shows the mevalonate pathway in Mycobacterium marinum is dispensable in culture but supports metabolic flexibility under stress and during hypoxia.

The paper identifies IRF2 as a regulator of antibacterial responses in Mtb-infected macrophages through a genome-wide CRISPR screen, showing its inhibitory role in macrophage activation.

This study identifies a genetic switch involving IS1245 transposition and Erp/MarP that controls colony morphology, virulence, and antibiotic resistance in Mycobacterium avium.

The paper identifies UFMylation as a suppressor of Type I IFN signaling during M. tuberculosis infection of human macrophages through a CRISPR-interference screen.

This study shows that SARS-CoV-2's PLpro activates nociceptors to cause sneezing and pain by triggering TRPA1-dependent responses.

This paper describes a method to efficiently generate genetically modified primary human myeloid cells using CRISPR-Cas9 RNP nucleofection, demonstrating its utility in studying HIV-1 infection and myeloid cell biology.

The paper identifies Mtb-human protein-protein interactions, showing LpqN antagonizes CBL, a host ubiquitin ligase that balances anti-viral and anti-bacterial responses in macrophages.