The paper identifies an operon in MRSA encoding two secreted nucleases that contribute to virulence, showing attenuation in a mouse model when mutated.

bioRxiv · Aug 27, 2026 · PreprintMicrobiology

An unusual genetic switch controls Mycobacterium avium pathogenesis, antibiotic resistance and colony morphology

Hannah Nilsson, Zoe Netter, Miles I. Tuncel, Nicholas E. Garelis, Nabila Siddiqui, Mira Semaan, Rita M. McCall, Kyla Dangerfield, Ella K. Cox, Laura Britt, Mark Voorhies, Allison W. Roberts, Gabriel Mitchell, Gerard A. Cangelosi, William R. Jacobs, , Jeffery S. Cox

This study identifies a genetic switch involving IS1245 transposition and Erp/MarP that controls colony morphology, virulence, and antibiotic resistance in Mycobacterium avium.

bioRxiv · Jul 28, 2025 · PreprintMicrobiology

An Mtb-Human Protein-Protein Interaction Map Reveals that Bacterial LpqN Antagonizes CBL, a Host Ubiquitin Ligase that Regulates the Balance Between Anti-Viral and Anti-Bacterial Responses

Bennett H. Penn, Zoe Netter, Jeffrey R. Johnson, John Von Dollen, Gwendolyn M. Jang, Tasha Johnson, Yamini M. Ohol, Cyrus Maher, Samantha L. Bell, Kristina Geiger, Xiaotang Du, Alex Choi, Trevor Parry, Mayumi Naramura, Chen Chen, , Nevan J. Krogan

The paper identifies Mtb-human protein-protein interactions, showing LpqN antagonizes CBL, a host ubiquitin ligase that balances anti-viral and anti-bacterial responses in macrophages.

bioRxiv · Oct 17, 2017 · PreprintMicrobiology