William R. Jacobs

The paper identifies pks12 as an in vivo essential gene in Mtb by combining genomic, metabolomic, and phenotypic analyses, revealing its role in mycolyl lipid synthesis and host-pathogen interface structure.

This paper develops a BSL-2-compatible intravital imaging protocol to visualize early Mycobacterium tuberculosis interactions with murine lung macrophages in real time.

This study investigates the role of NucS-mediated non-canonical mismatch repair in Mycobacterium tuberculosis and finds it does not significantly affect resistance to key antibiotics.

This study shows that deleting the ESX-5 secretion system in Mycobacterium tuberculosis reduces ESX-5 substrate secretion, increases ESX-1 substrates, decreases ESX-3 expression, and alters cell morphology and antibiotic susceptibility.

This study identifies a genetic switch involving IS1245 transposition and Erp/MarP that controls colony morphology, virulence, and antibiotic resistance in Mycobacterium avium.

This study shows that loss of the PPE71-38 locus in Mycobacterium tuberculosis Lineage 2 increases stress response gene expression and triglyceride levels, contributing to hypervirulence.

This paper demonstrates a viral vaccine strategy using BCG-induced Th cells to enhance antibody responses against Ebola virus, providing protection in a mouse model.

This study shows that IKEPLUS, a recombinant Mycobacterium smegmatis strain, provides better protection against Mtb infection than BCG in mice when grown in low zinc media.

This paper investigates a novel tuberculosis vaccine strategy using a triple auxotrophic Mtb strain, showing intravenous immunization provides superior protection compared to subcutaneous BCG in mice.