Huihui Ye

This study identifies a functional cooperation between nuclear pore complexes and m6A signaling that promotes castration-resistant prostate cancer by linking mRNA export to cholesterol biosynthesis and androgen production.

This study shows that in prostate cancer with TMPRSS2:ERG fusion, androgen deprivation increases AKT activation, which may reduce the effectiveness of AR-targeted therapy, suggesting combination therapy could be beneficial.

The paper shows that ctDNA is undetectable in localized prostate cancer but present in metastatic cases, suggesting lower dissemination and detectability in early stages.