A Conserved Flexible N-Terminal Domain Tunes the Calcium Sensitivity of Sorcin by Stabilizing Its Active Conformation
Qiushi Ye, Angela Wu, Kathleen Joyce Carillo, Ibrahim Damilare Boyenle, Holly R. Hemesath, Yanan He, Nicolas Delaeter, Jaekyun Jeon, John P. Orban, Lei Zhang, Yanxin Liu
This study identifies the flexible N-terminal domain of Sorcin as a critical regulator that enhances Ca2+ responsiveness by stabilizing its active conformation through dynamic contacts.
bioRxiv · Aug 4, 2026 · PreprintBiophysics