Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson disease
Pierre Garcia, Wiebke M. Wemheuer, Oihane Uriarte Huarte, Kristopher J. Schmit, Annette Masuch, Simone Brioschi, Andreas Weihofen, Eric Koncina, Djalil Coowar, Tony Heurtaux, Enrico Glaab, Rudi Balling, Carole Sousa, Alessandro Michelucci, Tony Kaoma, , Manuel Buttini
The paper investigates the role of alpha-synuclein spreading and inclusions in Parkinson disease using a mouse model, finding that neurodegeneration and microgliosis occur independently of inclusions.
bioRxiv · Aug 5, 2020 · PreprintNeuroscience