Neurons as biosensors for discriminating neurological disorders in a brain-on-chip platform: Application to Alzheimer s Disease using patient CSF
Louise Miny, Jessica Rontard, Ahmad Allouche, Nicolas Violle, Louise Dubuisson, Aurélie Batut, Alexandre Ponomarenko, Rania Talbi, Hélène O. B. Gautier, B. G. C. Maisonneuve, Serge Roux, Florian Larramendy, Thibault Honegger, Isabelle Quadrio
The paper uses a brain-on-chip platform with human neurons to differentiate Alzheimer's disease and healthy CSF samples based on electrophysiological responses to Aβ peptides.
bioRxiv · Aug 23, 2024 · PreprintNeuroscience