Author

Simone Brioschi

Washington University in St. LouisORCID 0000-0002-3849-3926Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Marco ColonnaiD· 2 shared Ademar Bynum· 1 shared Ahmad Allouche· 1 shared Alejandro Medina EncisoiD· 1 shared Alessandro MichelucciiD· 1 shared Andreas WeihofeniD· 1 shared Anna E. EastmaniD· 1 shared Anne BrunetiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

Marco ColonnaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintMay 20, 2026

Somatic mutations reveal the ontogeny of human microglia

Julia A. Belk, Yaowen Zhang, Quanming Shi…·Siddhartha Jaiswal

This study uses somatic mutations to track marrow-derived cell infiltration into the human brain, finding widespread microglia replenishment and a protective link between clonal hematopoiesis and Alzheimer's disease.

3 citations

humanwhole-genome sequencing

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ImmunologyNeuronPeer-reviewedMar 11, 2026

Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia

Siling Du, Feiya Ou, Antoine Drieu…·Jonathan Kipnis

The paper identifies distinct transcriptional and epigenetic profiles of brain-engrafted monocyte-derived macrophages compared to microglia, showing their origin from peripheral blood and skull bone marrow.

30 citationstop 1%

mousebulk RNA-seq

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NeurosciencebioRxivPreprintAug 5, 2020

Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson disease

Pierre Garcia, Wiebke M. Wemheuer, Oihane Uriarte Huarte…·Manuel Buttini

The paper investigates the role of alpha-synuclein spreading and inclusions in Parkinson disease using a mouse model, finding that neurodegeneration and microgliosis occur independently of inclusions.

1 citation

mousestatistical model

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