Western-style diet-induced microbial shifts and inflammation reprogram c-Kit⁺ secretory cells into targets for tumor initiation
Sara Silva, Paola Procopio, Valeriya V. Zinina, Solveig Turss, Rafael R. Segura Muñoz, Seyram Segbefia, Sena Bae, Lior Lobel, Luigi L. Nardella, Andrea Sacchetti, Rosalie Joosten, Coen Linn, Susanna Plugge, Mathijs P. Verhagen, Fatma Aktuna, , Mark R. Schmitt
This study shows that a Western-style diet reprograms c-Kit⁺ secretory cells into tumor-initiating cells via microbial shifts and inflammation.
bioRxiv · Jul 19, 2026 · PreprintCell Biology