IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies
Wen Gu, Nicole Wilkinson, Carine Fillebeen, Darren M. Blackburn, Korin Sahinyan, Éric Bonneil, Tao Zhao, Zhi Luo, Vahab D. Soleimani, Vincent R. Richard, Christoph H. Borchers, ALBERT KOULMAN, Benjamin Jenkins, Bernhard Michalke, Hans Zischka, , Kostas Pantopoulos
This study shows that IRP1 deficiency in mice leads to metabolic changes that protect against metabolic syndrome by altering mitochondrial function and improving insulin sensitivity.
JCI Insight · Jan 6, 2026Peer-reviewedPathology