Vahab D. Soleimani

This study identifies TCF4 as a downstream effector of PHF6 in neural stem cell regulation, showing its role in restricting self-renewal and rescuing BFLS phenotypes.

This study identifies cancer-driven suppression of muscle stem cell differentiation in cachectic mice through GDF15 and MMP9, revealing a new mechanism of muscle wasting.

This study shows that IRP1 deficiency in mice leads to metabolic changes that protect against metabolic syndrome by altering mitochondrial function and improving insulin sensitivity.

This study identifies a bidirectional OSMR-CLIC1 crosstalk that drives oncogenic pathways in glioblastoma and suggests targeting this interaction as a therapeutic strategy.

This study shows that the niche environment significantly influences skeletal muscle stem cell transcriptional activity, with some age-related changes being reversible through exposure to a young niche.

The paper applies single myofiber ATAC-Seq to analyze chromatin state changes in skeletal muscle under different conditions, revealing differences in chromatin accessibility between resting and regenerating myofibers.

This study shows that Myf6/MRF4 regulates myokine production and maintains the muscle stem cell pool by controlling signaling pathways like EGFR and STAT3.

This paper develops smfRNA-Seq to analyze the whole transcriptome of individual myofibers and finds aging causes significant changes in metabolic and structural gene expression.