Darren M. Blackburn

A Multiomic Analysis of Cachectic Mice Reveals Cancer Driven Suppression of Muscle Stem Cell Differentiation

This study identifies cancer-driven suppression of muscle stem cell differentiation in cachectic mice through GDF15 and MMP9, revealing a new mechanism of muscle wasting.

IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies

This study shows that IRP1 deficiency in mice leads to metabolic changes that protect against metabolic syndrome by altering mitochondrial function and improving insulin sensitivity.

Transcriptional Reprogramming of Skeletal Muscle Stem Cells by the Niche Environment

This study shows that the niche environment significantly influences skeletal muscle stem cell transcriptional activity, with some age-related changes being reversible through exposure to a young niche.

Application of ATAC-Seq for genome-wide analysis of the chromatin state at single myofiber resolution

The paper applies single myofiber ATAC-Seq to analyze chromatin state changes in skeletal muscle under different conditions, revealing differences in chromatin accessibility between resting and regenerating myofibers.

Myf6/MRF4 is a Myogenic Niche Regulator Required for the Maintenance of the Muscle Stem Cell Pool

This study shows that Myf6/MRF4 regulates myokine production and maintains the muscle stem cell pool by controlling signaling pathways like EGFR and STAT3.

High Resolution Genome Wide Expression Analysis of Single Myofibers Using SMART-Seq

This paper develops smfRNA-Seq to analyze the whole transcriptome of individual myofibers and finds aging causes significant changes in metabolic and structural gene expression.