Backbone extension acyl rearrangements enable cellular synthesis of proteins with internal β2-peptide linkages
Leah Tang Roe, Carly K. Schissel, Taylor L. Dover, Bhavana Shah, Noah X. Hamlish, Shuai Zheng, Diondra A. Dilworth, Nicole Wong, Zhongqi Zhang, Abhishek Chatterjee, Matthew B. Francis, Scott J. Miller, Alanna Schepartz
This paper introduces a method to synthesize proteins with internal β2-peptide linkages in cells by using a post-translational rearrangement after incorporating specific -hydroxy acid monomers.
bioRxiv · Oct 3, 2023 · PreprintSynthetic Biology