Matthew B. Francis

This paper develops a vaccine platform using MS2 viral capsids to deliver an Mtb antigen and STING agonist, reducing the required dose and cost while maintaining efficacy.

This study shows that delivering cGAMP via bacteriophage MS2 nanoparticles enhances STING activation and antitumor immunity in mice.

This paper develops a viral capsid-based vaccine platform using MS2 virus to display peptide antigens, demonstrating effective T-cell activation and MHC presentation in vitro.

This study develops a viral capsid-based delivery system for anionic CDN STING agonists, enhancing cell uptake and STING activation while avoiding toxicity.

This paper introduces a method to synthesize proteins with internal β2-peptide linkages in cells by using a post-translational rearrangement after incorporating specific -hydroxy acid monomers.