Author

Ann E. McDermott

Columbia UniversityORCID 0000-0002-9249-1649Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Andrew C. JohnsiD· 1 shared Anne E. van VlimmereniD· 1 shared Brayden Williams· 1 shared Cassandra A. ChartieriD· 1 shared Chengming HeiD· 1 shared Chi L.L. PhamiD· 1 shared Crystal Semaan· 1 shared D. A. KeedyiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Andrew C. JohnsORCID

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2 papers

Recent·Most cited

Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR

Chengming He, Nikhil R. Varghese, Eric G. Keeler, Chi L.L. Pham, Teng Xie, Brayden Williams, Stephan Tetter, Crystal Semaan, Karyn L. Wilde, Simon H. J. Brown, James C. Bouwer, Yann Gambin, Emma Sierecki, Megan C. Steain, Ruhong Zhou, , Ann E. McDermott

This paper reports the high-resolution structure of a viral:host hetero-amyloid complex between M45 and RIPK3, revealing its mechanism of inhibiting necroptosis.

Proceedings of the National Academy of Sciences · Apr 27, 2026Peer-reviewedBiophysics

Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction

Cassandra A. Chartier, Virgil A. Woods, Yunyao Xu, Anne E. van Vlimmeren, Andrew C. Johns, Marko Jovanović, Ann E. McDermott, D. A. Keedy, Neel H. Shah

This paper shows that Grb2 binding to PTP1B allosterically enhances its catalytic activity through structural changes, revealing a new regulatory mechanism for PTP1B in cell signaling.

Protein Science · Dec 26, 2024Peer-reviewedBiochemistry