Macrophage Cholesterol Homeostasis Underpins the role of Sertraline as an Adjunctive Agent in Tuberculosis Therapy.
Kanika Bisht, Riya Sahu, Sneha Vasudevan, Simran Jit, Nikita Bhor, Jitendra Kumar, Mahima Madan, Deepthi Shankaran, Sherry Bhalla, Nagasuma R Chandra, Vivek Rao
This paper shows sertraline enhances macrophage bactericidal activity against Mtb by rewiring cholesterol metabolism and activating inflammasome pathways.
bioRxiv · Jul 18, 2025 · PreprintImmunology