Author

Mahima Madan

Institute of Genomics and Integrative Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Organism:non-human primate· 1

Frequent Co-Authors

Kanika BishtiD· 3 shared Vivek RaoiD· 2 shared Anita Kamra VermaiD· 1 shared Deepthi ShankaraniD· 1 shared Jitendra Kumar· 1 shared Largee BiswasiD· 1 shared Manjula SinghiD· 1 shared Monica Yadav· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

Kanika BishtORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Rapid Screening and Validation of Intracellularly Active Antimycobacterial Compounds with Efficacy in Cellular and Murine Tuberculosis Models

Mahima Madan, Kanika Bisht, Neetu Sehrawat, Vivek Rao

This paper validates a THP-1 macrophage model with Mycobacterium marinum for rapid screening of intracellular antimycobacterial compounds, identifying phenothiazines as effective adjuncts to TB therapy.

bioRxiv · Sep 23, 2025 · PreprintMicrobiology

Macrophage Cholesterol Homeostasis Underpins the role of Sertraline as an Adjunctive Agent in Tuberculosis Therapy.

Kanika Bisht, Riya Sahu, Sneha Vasudevan, Simran Jit, Nikita Bhor, Jitendra Kumar, Mahima Madan, Deepthi Shankaran, Sherry Bhalla, Nagasuma R Chandra, Vivek Rao

This paper shows sertraline enhances macrophage bactericidal activity against Mtb by rewiring cholesterol metabolism and activating inflammasome pathways.

bioRxiv · Jul 18, 2025 · PreprintImmunology

Sertraline enhances bacterial control by improving the pharmacodynamic -pharmacokinetic properties of frontline TB drugs

Kanika Bisht, Monica Yadav, Mahima Madan, Largee Biswas, Rajesh Pradhan, Rajeev Taliyan, Manjula Singh, Anita Kamra Verma, Vivek Rao

This study shows sertraline improves bacterial control in TB models by enhancing the pharmacodynamic-pharmacokinetic properties of TB drugs without altering their distribution or clearance.

bioRxiv · Jul 13, 2025 · PreprintMicrobiology