Author

Nikolay V. Rozhkov

Cold Spring Harbor Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Josh DubnauiD· 2 shared Molly HammelliD· 2 shared Andrea MalaspinaiD· 1 shared Avindra NathiD· 1 shared Bin ZhangiD· 1 shared Brent T. HarrisiD· 1 shared Colin SmithiD· 1 shared Dale J. LangeiD· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Josh DubnauORCID

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2 papers

Recent·Most cited

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Oliver H. Tam, Nikolay V. Rozhkov, Regina Shaw, Duyang Kim, Isabel Hubbard, Samantha Fennessey, Nadia Propp, Hemali P. Phatnani, Justin Y. Kwan, Dhruv Sareen, James Riley Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, Vivianna M. Van Deerlin, , John Ravits

The paper uses unsupervised machine learning to identify three molecular subtypes in ALS cortex samples, associated with oxidative stress, retrotransposon activation, and glial activation.

Cell Reports · Oct 1, 2019Peer-reviewedGenomics

Retrotransposon Activation Contributes to Neurodegeneration in a DrosophilaTDP-43 Model of ALS.

Lisa Krug, Nabanita Chatterjee, Rebeca Borges-Monroy, Stephen Hearn, Wen‐Wei Liao, Kathleen M. Morrill, Lisa Prazak, Yung-Heng Chang, Richard M. Keegan, Nikolay V. Rozhkov, Delphine Theodorou, Molly Hammell, Josh Dubnau

This paper shows that TDP-43 expression in Drosophila causes retrotransposon activation, leading to neurodegeneration through DNA damage and programmed cell death.

PLoS Genetics · Mar 16, 2017Peer-reviewedNeuroscience