Isabel Hubbard

This study investigates glial cell-intrinsic and non-cell autonomous toxicity in a Drosophila C9orf72 model by expressing different components of the G4C2 repeat expansion.

This study shows that TDP-43 pathology in Drosophila glial cells causes systemic toxicity, which can be reduced by knocking down SF2/SRSF1.

The paper uses unsupervised machine learning to identify three molecular subtypes in ALS cortex samples, associated with oxidative stress, retrotransposon activation, and glial activation.