Valeria Mezzano

Cardiomyocyte-specific plakophilin-2 loss is sufficient to induce aging and senescence of nonmyocytes. Relevance to arrhythmogenic cardiomyopathy.

This study shows that loss of PKP2 in cardiomyocytes induces pro-inflammatory senescence in non-myocytes and premature cardiac aging, linking desmosomal arrhythmogenic cardiomyopathy to cellular senescence and aging mechanisms.

Non-segmented unsupervised learning of multispectral whole slide images for robust analysis of tissue repair and regeneration

This paper introduces a segmentation-free method for analyzing multispectral whole slide images to study tissue repair and regeneration, revealing tissue compartments and dynamics without prior labels.

Population analysis and immunologic landscape of melanoma in people living with HIV indicate impaired antitumor immunity

This paper analyzes melanoma in people living with HIV, finding impaired antitumor immunity, delayed ICI treatment, and an immunosuppressive tumor microenvironment.

Characterization of tumor heterogeneity through segmentation-free representation learning

The paper introduces a segmentation-free vision transformer, CANVAS, to discover and characterize tumor microenvironment signatures from high-dimensional multiplexed images, identifying a monocytic signature linked to poor prognosis.